Backbone flexibility in computational protein design
نویسندگان
چکیده
منابع مشابه
Side-chain and backbone flexibility in protein core design.
We have developed a computational approach for the design and prediction of hydrophobic cores that includes explicit backbone flexibility. The program consists of a two-stage combination of a genetic algorithm and monte carlo sampling using a torsional model of the protein. Backbone structures are evaluated either by a canonical force-field or a constraining potential that emphasizes the preser...
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ژورنال
عنوان ژورنال: Current Opinion in Biotechnology
سال: 2009
ISSN: 0958-1669
DOI: 10.1016/j.copbio.2009.07.006